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GWC
Technologies |
505
S. Rosa Rd
Madison, WI 53719
USA |
| 608.441.2726 |
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LOOK WHO IS
USING GWC’S PRODUCTS |
Analytical
Chemists Prof. Giuseppe Spoto & colleagues, Dipartimento
di Scienze Chimiche, Università di Catania, Italy
Dr. Spoto is one of the most prolific users of GWC’s products.
In collaboration with colleagues at several institutions, he
uses GWC’s products for development of biosensors and
materials science
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applications. In one study, Dr.
Spoto et al. used GWC’s SPRimager® platform to
show that a synthetic Superoxide dismutase mimic interacts strongly
with the lectin Ricinus communis agglutinin (RCA120). This model
system is used to explore therapeutic approaches to inflammatory
disease. Using kinetic analysis, this work yielded specific
affinity measurements for the interaction.
Dr. Spoto’s group was also part of a collaboration to
develop methods to monitor the activity of matrix metalloproteinases
(MMPs), proteins involved in degrading the extracellular matrix.
They anchored functional MMP catalytic domain to an SPRchip™,
then determined surface coverage using GWC’s wavelength-scanning
FT-SPR system. This analysis was followed by analysis using
electrospray-ionization mass spectrometry to monitor
MMP activity. The results establish a robust surface-based
approach to monitoring MMP activity.
On the materials science front, Dr. Spoto was the first researcher
to publish a paper that reports data obtained using all three
GWC Technologies product platforms: SPR imaging, wavelength-scanning
SPR and, using GWC’s SSD, PMIRRAS (reflectivity) measurements.
This project showed
that the electrochemically switchable Cu2+ complex of a 1,3
alternate bis(dipyridyl)calix[4]arene derivative forms self-assembled
monolayers on Au(111) surfaces. The work is a key finding in
the quest to develop novel microelectronic devices. |
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GWC Technologies
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